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【medical-news】【资讯翻译】胎儿干细胞在诱导母亲心脏修复中起着重要作用
肿瘤研究所(医学生)
【medical-news】【资讯翻译】胎儿干细胞在诱导母亲心脏修复中起着重要作用
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认领翻译的战友请跟帖注明，&认领本文翻译，48小时内未完成，请其他站友认领&Researchers from Mount Sinai School of Medicine have discovered the therapeutic benefit of fetal stem cells in helping the maternal heart recover after heart attack or other injury. The research, which marks a significant advancement in cardiac regenerative medicine, was presented today at the American Heart Association's (AHA) Scientific Sessions 2011 in Orlando, Florida, and is also published in the current issue of Circulation Research, a journal of the AHA.In the first study of its kind, the Mount Sinai researchers found that fetal stem cells from the placenta migrate to the heart of the mother and home to the site where an injury, such as a heart attack, occurred. The stem cells then reprogram themselves as beating heart stem cells to aid in its repair. The scientists also mimicked this reprogramming in vitro, showing that the fetal cells became spontaneously beating heart cells in cell culture, which has broad-reaching implications in treating heart disease.Previous studies have documented a phenomenon in which half of women with a type of heart failure called peripartum cardiomyopathy saw their condition spontaneously recover in the months following pregnancy. Based on this evidence, the Mount Sinai team wanted to determine whether fetal stem cells played a role in maternal recovery.They evaluated the hearts of pregnant female mice that underwent mid-gestation heart injury and survived. Using green fluorescent protein in the fetuses to tag the fetal stem cells derived from the placenta, they found that the green fluorescent stem cells homed to the injured hearts of their mothers, grafted onto the damaged tissue, and differentiated into smooth muscle cells, blood vessel cells, or another type of heart cell called cardiomyocytes.&Our research shows that fetal stem cells play an important role in inducing maternal cardiac repair,& said Hina Chaudhry, MD, Director of Cardiovascular Regenerative Medicine at Mount Sinai School of Medicine, and principal investigator of the study. &This is an exciting development that has far-reaching therapeutic potential.&With a broader understanding of the role of fetal stem cells, Dr. Chaudhry and her team then isolated the fetal cells that had grafted onto the maternal hearts and recreated the environment in vitro. They found that the cells spontaneously differentiated into cardiac cells in cell culture as well.Until now, researchers have had limited success in discovering the regenerative potential of stem cells in heart disease. The use of bone marrow cells in cardiac regeneration has largely failed as well. Dr. Chaudhry's research team has found that fetal cells may potentially be a viable therapeutic agent, both through in vivo and in vitro studies.&Identifying an ideal stem cell type for cardiac regeneration has been a major challenge in heart disease research,& said Dr. Chaudhry. &Embryonic stem cells have shown potential but come with ethical concerns. We've shown that fetal stem cells derived from the placenta, which is discarded postpartum, have significant promise. This marks a significant step forward in cardiac regenerative medicine.&These findings have implications beyond cardiovascular disease. The fetal stem cells traveled only to the injury site on the damaged heart, and not to other undamaged organs, meaning research on the benefit of these cells on organs damaged by other diseases would be beneficial. Importantly, a significant percentage of the fetal cells isolated from maternal hearts express a protein called Cdx2, which indicates that the cells may not have developed mature immune recognition molecules and therefore are unlikely to cause a negative immune response, which occurs in organ transplant.&Our study shows the promise of these cells beyond just cardiovascular disease,& said Dr. Chaudhry. &Additionally, this breakthrough greatly underscores the importance of translational research. As a clinician who also has a basic science laboratory, I am in the unique position to assess the needs of my patients, evaluate how they respond to treatment and recover from illness, and bring that anecdotal knowledge to the experiments in my lab.&
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Researchers from Mount Sinai School of Medicine have discovered the therapeutic benefit of fetal stem cells in helping the maternal heart recover after heart attack or other injury. The research, which marks a significant advancement in cardiac regenerative medicine, was presented today at the American Heart Association's (AHA) Scientific Sessions 2011 in Orlando, Florida, and is also published in the current issue of Circulation Research, a journal of the AHA.西奈山医学院的研究人员发现胎儿干细胞在母体心脏病发作或其他损伤后诱导心脏修复的过程中有着良好的治疗效果。该研究标志着心脏再生医学取得了重要进展，今天在美国心脏协会（AHA）的佛罗里达州奥兰多2011届科学会议上发表，同时还在一个叫《循环研究》的AHA所属杂志的近期期刊上发表。In the first study of its kind, the Mount Sinai researchers found that fetal stem cells from the placenta migrate to the heart of the mother and home to the site where an injury, such as a heart attack, occurred. The stem cells then reprogram themselves as beating heart stem cells to aid in its repair. The scientists also mimicked this reprogramming in vitro, showing that the fetal cells became spontaneously beating heart cells in cell culture, which has broad-reaching implications in treating heart disease.作为同类研究中的第一个，西奈山医学院的研究人员发现胎盘中的胎儿干细胞在母体心脏损伤（比如心脏病发作）后会迁往母体心脏受损区域。然后干细胞自身重组为跳动的心脏干细胞，以帮助其修复。科学家们在体外同样模仿了这种重组，显示胎儿干细胞子在细胞环境中能够自发地变为跳动的心脏细胞，这在心脏病治疗中有着广泛而深远的意义。Previous studies have documented a phenomenon in which half of women with a type of heart failure called peripartum cardiomyopathy saw their condition spontaneously recover in the months following pregnancy. Based on this evidence, the Mount Sinai team wanted to determine whether fetal stem cells played a role in maternal recovery.先前的研究证明存在着这样一种现象：在半数患有围生期心肌病的妇女中，在妊娠数月后她们的病情会自然恢复。正是基于这一点，西奈山医学院的研究组就想确定是否胎儿干细胞在母体恢复的过程中起作用。They evaluated the hearts of pregnant female mice that underwent mid-gestation heart injury and survived. Using green fluorescent protein in the fetuses to tag the fetal stem cells derived from the placenta, they found that the green fluorescent stem cells homed to the injured hearts of their mothers, grafted onto the damaged tissue, and differentiated into smooth muscle cells, blood vessel cells, or another type of heart cell called cardiomyocytes.他们检测了在妊娠中期心脏损伤后存活下来的雌鼠的心脏。他们在胎儿中使用绿荧光蛋白标记胎盘中的胎儿干细胞，发现绿荧光蛋白标记的干细胞定植到了母体损伤的心脏中，嫁接在损伤组织中，分化为平滑肌细胞、血管细胞或另外一种叫做心肌细胞的心脏细胞。&Our research shows that fetal stem cells play an important role in inducing maternal cardiac repair,& said Hina Chaudhry, MD, Director of Cardiovascular Regenerative Medicine at Mount Sinai School of Medicine, and principal investigator of the study. &This is an exciting development that has far-reaching therapeutic potential.&Hina Chaudhry，西奈山医学院心血管再生医学博士生导师同时也是该研究的主要研究者，说：“我们的研究显示胎儿干细胞在诱导母体心脏修复过程中起着重要的作用，这是一个振奋人心的进展，它有着极其深远的治疗可行性。”With a broader understanding of the role of fetal stem cells, Dr. Chaudhry and her team then isolated the fetal cells that had grafted onto the maternal hearts and recreated the environment in vitro. They found that the cells spontaneously differentiated into cardiac cells in cell culture as well.随着对胎儿干细胞功能的进一步认识，Chaudhry医生何她的研究组将嫁接在母体心脏的胎儿干细胞分离出来，并在体外重新激活细胞环境。他们发现这些胎儿干细胞在细胞环境中同样可以自发分化为心脏细胞。Until now, researchers have had limited success in discovering the regenerative potential of stem cells in heart disease. The use of bone marrow cells in cardiac regeneration has largely failed as well. Dr. Chaudhry's research team has found that fetal cells may potentially be a viable therapeutic agent, both through in vivo and in vitro studies.迄今为止，研究人员仅有限地成功发现心脏病中干细胞的再生蛋白。将骨髓细胞用于心脏再生也很大程度上失败了。Chaudhry医生的研究者发现胎儿细胞也许能够成为体内、体外研究较为可行的治疗中介。&Identifying an ideal stem cell type for cardiac regeneration has been a major challenge in heart disease research,& said Dr. Chaudhry. &Embryonic stem cells have shown potential but come with ethical concerns. We've shown that fetal stem cells derived from the placenta, which is discarded postpartum, have significant promise. This marks a significant step forward in cardiac regenerative medicine.&“为心脏再生识别理想的干细胞类型已成为心脏病研究的一个主要挑战，”Chaudhry医生说，“胚胎干细胞有可行性，但存在着伦理方面的关注。我们已经证实来自于胎盘的胎儿干细胞（在产后随即被遗弃）有很大希望。这标志着心脏再生医学迈出了重要的一步。”These findings have implications beyond cardiovascular disease. The fetal stem cells traveled only to the injury site on the damaged heart, and not to other undamaged organs, meaning research on the benefit of these cells on organs damaged by other diseases would be beneficial. Importantly, a significant percentage of the fetal cells isolated from maternal hearts express a protein called Cdx2, which indicates that the cells may not have developed mature immune recognition molecules and therefore are unlikely to cause a negative immune response, which occurs in organ transplant.这些发现已经超越了心脏病的范畴。胎儿干细胞仅仅移动到被损坏心脏的损伤区，而不移动到其他未受损坏的器官，意味着研究这些细胞对于其他疾病引起的其他器官损伤的益处可能会有所收获。重要的是，相当一部分从母体分离出来的胎儿干细胞表达一种叫Cdx2的蛋白，这就意味着这种细胞也许还没有产生出成熟的免疫识别分子，因此不太可能出现发生在器官移植中的有害免疫反应。&Our study shows the promise of these cells beyond just cardiovascular disease,& said Dr. Chaudhry. &Additionally, this breakthrough greatly underscores the importance of translational research. As a clinician who also has a basic science laboratory, I am in the unique position to assess the needs of my patients, evaluate how they respond to treatment and recover from illness, and bring that anecdotal knowledge to the experiments in my lab.& “我们的研究显示这些细胞的潜力并不局限于心脏病，”Chaudhry医生说，“另外，这一突破性进展很在大程度上改写了移植研究的重要性。作为一名拥有基础科学实验室的临床医生，评估患者的需要、评价他们对治疗的反应和疾病的恢复情况并将这些轶事一样的知识带到实验室的研究中，我的位置可谓得天独厚。”
mmhx2233 edited on
回复：【medical-news】【资讯翻译】胎儿干细胞在诱导母亲心脏修复中起着重要作用
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西奈山医学院的研究人员发现胎儿干细胞在母体心脏病发作或其他损伤后诱导心脏修复的过程中有着良好的治疗效果。该研究标志着心脏再生医学取得了重要进展，今天在美国心脏协会（AHA）的佛罗里达州奥兰多2011届科学会议上发表，同时还在一个叫《循环研究》的AHA所属杂志的近期期刊上发表。作为同类研究中的第一个，西奈山医学院的研究人员发现胎盘中的胎儿干细胞在母体心脏损伤（比如心脏病发作）后会迁往母体心脏受损区域。然后干细胞自身重组为跳动的心脏干细胞，以帮助其修复。科学家们在体外同样模仿了这种重组，显示胎儿干细胞子在细胞环境中能够自发地变为跳动的心脏细胞，这在心脏病治疗中有着广泛而深远的意义。先前的研究证明存在着这样一种现象：在半数患有围生期心肌病的妇女中，在妊娠数月后她们的病情会自然恢复。正是基于这一点，西奈山医学院的研究组就想确定是否胎儿干细胞在母体恢复的过程中起作用。他们检测了在妊娠中期心脏损伤后存活下来的雌鼠的心脏。他们在胎儿中使用绿荧光蛋白标记胎盘中的胎儿干细胞，发现绿荧光蛋白标记的干细胞定植到了母体损伤的心脏中，嫁接在损伤组织中，分化为平滑肌细胞、血管细胞或另外一种叫做心肌细胞的心脏细胞。Hina Chaudhry，西奈山医学院心血管再生医学博士生导师同时也是该研究的主要研究者，说：“我们的研究显示胎儿干细胞在诱导母体心脏修复过程中起着重要的作用，这是一个振奋人心的进展，它有着极其深远的治疗可行性。”随着对胎儿干细胞功能的进一步认识，Chaudhry医生何她的研究组将嫁接在母体心脏的胎儿干细胞分离出来，并在体外重新激活细胞环境。他们发现这些胎儿干细胞在细胞环境中同样可以自发分化为心脏细胞。迄今为止，研究人员仅有限地成功发现心脏病中干细胞的再生蛋白。将骨髓细胞用于心脏再生也很大程度上失败了。Chaudhry医生的研究者发现胎儿细胞也许能够成为体内、体外研究较为可行的治疗中介。“为心脏再生识别理想的干细胞类型已成为心脏病研究的一个主要挑战，”Chaudhry医生说，“胚胎干细胞有可行性，但存在着伦理方面的关注。我们已经证实来自于胎盘的胎儿干细胞（在产后随即被遗弃）有很大希望。这标志着心脏再生医学迈出了重要的一步。”这些发现已经超越了心脏病的范畴。胎儿干细胞仅仅移动到被损坏心脏的损伤区，而不移动到其他未受损坏的器官，意味着研究这些细胞对于其他疾病引起的其他器官损伤的益处可能会有所收获。重要的是，相当一部分从母体分离出来的胎儿干细胞表达一种叫Cdx2的蛋白，这就意味着这种细胞也许还没有产生出成熟的免疫识别分子，因此不太可能出现发生在器官移植中的有害免疫反应。“我们的研究显示这些细胞的潜力并不局限于心脏病，”Chaudhry医生说，“另外，这一突破性进展在很大程度改写了移植研究的重要性。作为一名拥有基础科学实验室的临床医生，评估患者的需要、评价他们对治疗的反应和疾病的恢复情况并将这些轶事一样的知识带到实验室的研究中，我的位置可谓得天独厚。”
mmhx2233 edited on
关于丁香园英语双向翻译：他们在我们将来的生活中起到重要作用。_百度知道
英语双向翻译：他们在我们将来的生活中起到重要作用。
提问者采纳
他们在我们将来的生活中起到重要作用。 They live in our future plays an important role.
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They will take an important part in our future.
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出门在外也不愁求翻译 1李雷是我的一位老朋友 2明年 我们要更加努力工作 3他们对我的生活和学习都很关心 4从餐馆订餐是个节省时间的办法 5朋友在我们的生活中起重要作用 6他积极从事英语教学并帮助失学儿童
求翻译 1李雷是我的一位老朋友 2明年 我们要更加努力工作 3他们对我的生活和学习都很关心 4从餐馆订餐是个节省时间的办法 5朋友在我们的生活中起重要作用 6他积极从事英语教学并帮助失学儿童
Li Lei is one of my old friendWe have to work harder next yearThey are my life and learning are very concerned aboutOrdering from the restaurant is a time-saving wayFriends in our lives plays an important roleHe is actively engaged in the teaching of English and to help
school children
英翻中 l don&t think the computer is made in canada the journey of a thousand miles begins with a single step
不认为电脑是加拿大制造的千里之行，始于足下
李雷是我的一位老朋友：Li lei is one of my old friends
明年我们要更加努力工作：Next year we will work harder
他们对我的生活和学习都很关心：They have on my life and study are very concerned about
从餐馆订餐是个节省时间的办法：From the restaurant meal is a way to save time
朋友在我们的生活中起重要作用：Friends in our life plays an important role
他积极从事英语教学并帮助失学儿童：He actively engaged in English teaching and help of children
谢了 那么继续 等会就采纳 1 this is a person you can rely on when you need help 2 he doesn&t run as fast as his brother
1 this is a person you can rely on when you need help：这是一个你可以依靠的人,在你需要帮助时。
2 he doesn't run as fast as his brother：他没有和他兄弟跑得一样快。
最后一题friend ship is one of life&s greatest treasures
friend ship is one of life's greatest treasures：友谊是人生最伟大的宝藏
这句话好，呵呵。
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学习帮助领域专家
当前分类官方群专业解答学科习题，随时随地的答疑辅导汉译英 1节日在生活中起着重要作用。 2我的英语取得了很大进步。 _百度知道
汉译英 1节日在生活中起着重要作用。 2我的英语取得了很大进步。
这就是我今天上午上课迟到的原因。英语
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Festivals play a major role in lifeI made great progress in English
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In our life,the festiv乏迹催克诎久挫勋旦魔al play an important role. I have made great progress in English
This is my being late for class this morning
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出门在外也不愁当前位置： &
求翻译：会计信息在社会经济运行中，起着举足轻重的作用。可是，目前我国乃至世界会计信息失真现象层出不穷，失真的会计信息会给投资者，企业，国家等使用会计信息者，带来严重危害。是什么意思？
会计信息在社会经济运行中，起着举足轻重的作用。可是，目前我国乃至世界会计信息失真现象层出不穷，失真的会计信息会给投资者，企业，国家等使用会计信息者，带来严重危害。
问题补充：
Accounting information plays an important role in the socio-economic operation. However, the phenomenon of China and the world of accounting information distortion, the distortion of accounting information will give the use of accounting information by investors, businesses, and countries, to bring
Accounting information in the social and economic running, play a vital role. However, at present, our country and the world phenomenon accounting information distortion, distortion of the accounting information to investors, businesses, the State, including the accounting information, result in ser
The accounting information in the social economy movement, is playing the pivotal role.But, at present our country and even the world accounting information distortion phenomenon emerges one after another incessantly, the distorted accounting information can give the investor, the enterprise, the co
Accounting information in the social economy, plays a decisive role. However, the endless stream of accounting information distortion in China and in the world now, distortion of the accounting information to investors, enterprises, using accounting information such as country, caused serious harm.
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