P2ry12 purinergic receptor P2Y, G-protein coupled 12 [Mus musculus (house mouse)] - Gene - NCBI
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P2ry12provided by
purinergic receptor P2Y, G-protein coupled 12provided by
Primary source
See related
protein coding
RefSeq status
E M C C V E M E E G R S M M M M Mus
Also known as
P2Y12; R Rik
See P2ry12 in
Annotation release
GRCm38.p3 ()
NC_ (263005, complement)
Build 37.2
previous assembly
MGSCv37 ()
NC_ (066753, complement)
Chromosome 3 - NC_
Genomic Sequence:
NC_ Chromosome 3 Reference GRCm38.p3 C57BL/6J
AC_ Chromosome 3 Alternate Mm_Celera
NC_ Chromosome 3 Reference MGSCv37 C57BL/6J
Go to nucleotide:
Related articles in PubMed
GeneRIFs: Gene References Into Functions
Title: Vessel wall, not platelet, P2Y12 potentiates early atherogenesis.
Title: ADP-induced bladder contractility is mediated by P2Y12 receptor and temporally regulated by ectonucleotidases and adenosine signaling.
Title: Signaling via P2Y12 may be critical for early stabilization of platelet aggregates.
Title: Platelet P2Y12 is involved in murine pulmonary metastasis.
Title: LPS-induced systemic inflammation is more severe in P2Y12 null mice.
Title: Microglial P2Y12 deficiency/inhibition protects against brain ischemia.
Title: Alteration of synaptic activity-regulating genes underlying functional improvement by long-term exposure to an enriched environment in the adult brain.
Title: Off-target effect of the Epac agonist 8-pCPT-2'-O-Me-cAMP on P2Y12 receptors in blood platelets.
Title: P2Y12 protects platelets from apoptosis via PI3k-dependent Bak/Bax inactivation.
Title: The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling.
BF392058 (e-PCR)
BE134084 (e-PCR)
Inferred from Sequence Orthology
Inferred from Mutant Phenotype
Inferred from Electronic Annotation
Inferred from Electronic Annotation
Inferred from Electronic Annotation
Evidence Code
Inferred from Mutant Phenotype
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Mutant Phenotype
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Mutant Phenotype
Inferred from Electronic Annotation
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Direct Assay
Inferred from Sequence Orthology
Inferred from Electronic Annotation
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Mutant Phenotype
Inferred from Sequence Orthology
Inferred from Genetic Interaction
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Electronic Annotation
Evidence Code
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Sequence Orthology
Inferred from Electronic Annotation
Inferred from Biological aspect of Ancestor
Inferred by Curator
Inferred from Sequence Orthology
Inferred from Electronic Annotation
Inferred from Sequence Orthology
Inferred from Electronic Annotation
Preferred Names
P2Y purinoceptor 12
P2Y purinoceptor 12
These reference sequences exist independently of genome builds.
These reference sequences are curated independently of the genome
annotation cycle, so their versions may not match the RefSeq versions in the current
genome build. Identify version mismatches by comparing the version of the RefSeq in
this section to the one reported in
mRNA and Protein(s)
P2Y purinoceptor 12
Status: VALIDATED
Source sequence(s)
Consensus CDS
UniProtKB/TrEMBL
UniProtKB/TrEMBL
UniProtKB/Swiss-Prot
Conserved Domains (1)
Location:55 → 304
7tm_1; 7 transmembrane receptor (rhodopsin family)
The following sections contain reference sequences that belong to a
specific genome build.
Reference GRCm38.p3 C57BL/6J
NC_ Reference GRCm38.p3 C57BL/6J
mRNA and Protein(s)
UniProtKB/TrEMBL
UniProtKB/Swiss-Prot
Conserved Domains (1)
Location:55 → 304
7tm_1; 7 transmembrane receptor (rhodopsin family)
UniProtKB/TrEMBL
UniProtKB/Swiss-Prot
Conserved Domains (1)
Location:55 → 304
7tm_1; 7 transmembrane receptor (rhodopsin family)
UniProtKB/TrEMBL
UniProtKB/Swiss-Prot
Conserved Domains (1)
Location:55 → 304
7tm_1; 7 transmembrane receptor (rhodopsin family)
Alternate Mm_Celera
AC_ Alternate Mm_Celera
Protein Accession
GenPept Link
UniProtKB Link
The following
resources are supplied by external providers. These providers are responsible for maintaining the links.
Interologous Interaction Database
Allen Brain Atlas
CREB Target Gene Database
FuncBase Gene Function Prediction Viewer
GeneNetwork
GoPubMed Proteins
Guide to Pharmacology
IUPHAR Database of Receptors and Ion Channels
Immunological Genome Project
Ingenuity Pathways Analysis
KOMP Repository
Kyoto Encyclopedia of Genes and Genomes
NIA Mouse Gene Index
OrthoDB: The Hierarchical Catalog of Eukaryotic Orthologs
PhosphoSitePlus
Protein Ontology Consortium
iHOP - Information Hyperlinked over Proteins
Addgene Non-profit plasmid repository
ExactAntigen/Labome
GeneCopoeia Inc.
Life Technologies
GeneWeaver
InterologFinder.org
QIAGEN GeneGlobe
Supplemental Content
Order cDNA clone
BioProjects related to a gene
BioSystems
Links from Gene to CCDS are established if a gene encodes a protein sequence that is a member of a Consensus CDS (CCDS).
Conserved Domain Database
Links between Entrez Gene and Conserved Domain Database (CDD) are calculated from the domains annotated by the CDD group on Reference Sequence proteins.
Link from Gene to dbVar
Full text in PubMedCentral identified from shared sequence links
Overlapping genes and two nearest non-overlapping genes on either side
Genome records having the gene annotated on corresponding genomic reference sequence.
Related GEO
Links between HomoloGene and Gene are provided by the HomoloGene group when a gene is included in a HomoloGene record.
These links are maintained by the Map Viewer group and are provided when a GeneID is annotated on a map for the same species.
Link to related Nucleotide entry
Related Probe entry
Link to related protein entry
PubChem Compounds
PubChem Substances
Links between Gene and PubMed are the result of the following:
1. Manual curation within NCBI. Part of the process of generating a REVIEWED RefSeq is an analysis of the current literature. Papers that are seminal in defining the gene, its sequence, and its function are added to the record at that time. Alert users point out gaps or errors in papers associated with a Gene record. These messages are reviewed and implemented as required.
2. Integration of information from other public databases. Gene integrates gene-citation from resources external to NCBI such as model organism-specific databases, Gene Ontology (GO), groups curating interactions, and sequence databases. The assumption in using these source is that they report citations specific to a gene in a known species. Gene does not process citations from OMIM automatically, because many of citations in OMIM refer to studies of genes in species other than human.
GeneRIF -- Gene Reference Into Function
Staff of the Index Section in the National Library of Medicine review the current literature. When they find articles focused on the structure and function of a gene, they write a brief summary of the impact of the paper and make the connection between the citation (PubMed) and Gene. An interface exists for interested users to submit such data as well.
http://www.ncbi.nlm.nih.gov/projects/GeneRIF/GeneRIFhelp.html
Citations in PubMed identified from shared sequence and PMC links.
Link to Protein RefSeqs
Link to Nucleotide RefSeq RNAs
Related SNP records
SNPs linked from GeneView
Gene Genotype Report
Link to related taxonomy entry
Links are provided between Gene and UniGene when both databases calculate links to the same mRNA record (gi).
P2ry12 purinergic receptor P2Y, G-protein coupled 12 [Mus musculus]Gene ID:70839
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External link. Please review our .Protein knowledgebaseProtein sets from fully sequenced genomesSequence clustersSupporting dataSelect one of the options below to target your search:Sequence archiveHelp pages, FAQs, UniProtKB manual, documents, news archive, etc.FunctioniReceptor for ADP and ATP coupled to G-proteins that inhibit the adenylyl cyclase second messenger system. Required for normal platelet aggregation and blood coagulation."P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.", , , , , , , ,
[] [] []Cited for: FUNCTION, DISRUPTION PHENOTYPE. SitesFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsBinding sitei1ADPBinding sitei1ADP; via carbonyl oxygenBinding sitei1ADPBinding sitei1ADPBinding sitei1ADPBinding sitei1ADPBinding sitei1ADPRegionsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsNucleotide bindingi4ADPNucleotide bindingi5ADPNucleotide bindingi4ADPGO - Molecular functioniGO - Biological processiKeywords - Molecular functioni, , Keywords - Biological processi, Enzyme and pathway databases
Reactomei P2Y receptors.
ADP signalling through P2Y purinoceptor 12.
G alpha (i) signalling events. Names & TaxonomyiProtein namesiRecommended name:P2Y purinoceptor 12Short name: P2Y12Gene namesiName:P2ry12OrganismiTaxonomic identifieri
[]Taxonomic lineagei &
Proteomesi Componenti: Chromosome 3 Organism-specific databases
MGIi P2ry12. Subcellular locationi; TopologyFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsTopological domaini33ExtracellularTransmembranei23H Name=1Topological domaini11CytoplasmicTransmembranei21H Name=2Topological domaini15ExtracellularTransmembranei21H Name=3Topological domaini24CytoplasmicTransmembranei20H Name=4Topological domaini23ExtracellularTransmembranei22H Name=5Topological domaini26CytoplasmicTransmembranei26H Name=6Topological domaini19ExtracellularTransmembranei20H Name=7Topological domaini43CytoplasmicGO - Cellular componentiKeywords - Cellular componenti, Pathology & BiotechiDisruption phenotypeiMice are viable and fertile, but display impaired blood coagulation, due to defects in platelet aggregation and thrombus formation."P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.", , , , , , , ,
[] [] []Cited for: FUNCTION, DISRUPTION PHENOTYPE. PTM / ProcessingiMolecule processingFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsChaini347P2Y purinoceptor 12PRO_Amino acid modificationsFeature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActionsGlycosylationi1N-linked (GlcNAc...)Glycosylationi1N-linked (GlcNAc...)Disulfide bondiModified residuei1PhosphoserineModified residuei1PhosphoserineDisulfide bondiKeywords - PTMi, , Proteomic databases
PRIDEi PTM databases
PhosphoSitei ExpressioniGene expression databases
ExpressionAtlasi baseline and differential.
Genevestigatori InteractioniProtein-protein interaction databases
STRINGi Structurei3D structure databases
ProteinModelPortali
SMRi Positions
MobiDBiFamily & DomainsiDomainiThe transmembrane domain is composed of seven t most of these are not strictly perpendicular to the plane of the membrane, but are tilted and/or kinked. Agonist binding promotes a conformation change in the extracellular loops that leads to an inward movement of the transmembrane helices. Antagonists can bind to an overlapping site, but block the inward movement of the transmembrane helices (By similarity).Sequence similaritiesiBelongs to the .Keywords - Domaini, Phylogenomic databases
InParanoidi
PhylomeDBi
TreeFami Family and domain databases
InterProi GPCR_Rhodpsn.
GPCR_Rhodpsn_7TM.
P2Y12_rcpt.
PANTHERi PTHR24233:SF0. 1 hit.
Pfami 7tm_1. 1 hit.
PRINTSi GPCRRHODOPSN.
P2Y12PRNCPTR.
PROSITEi G_PROTEIN_RECEP_F1_2. 1 hit.
[]SequenceiSequence statusi: Complete.Q9CPV9-1 []
50MDVPGVNTTS ANTTFSPGTS TLCVRDYKIT QVLFPLLYTV LFFAGLITNS
100LAMRIFFQIR SKSNFIIFLK NTVISDLLMI LTFPFKILSD AKLGAGPLRT
150LVCQVTSVTF YFTMYISISF LGLITIDRYL KTTRPFKTSS PSNLLGAKIL
200SVVIWAFMFL ISLPNMILTN RRPKDKDVTK CSFLKSEFGL VWHEIVNYIC
250QVIFWINFLI VIVCYSLITK ELYRSYVRTR GSAKVPKKKV NVKVFIIIAV
300FFICFVPFHF ARIPYTLSQT RAVFDCSAEN TLFYVKESTL WLTSLNACLD
340 PFIYFFLCKS FRNSLTSMLR CSNSTSTSGT NKKKGQEGGE PSEETPM 34739,474May 31, 2001 - v1Checksum:iFE025F1BLASTProtParamProtScaleCompute pI/MWPeptideMassPeptideCutterSequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .
UniGeneiMm.422675. Genome annotation databases
Ensembli; ; . ; ; .
UCSCi mouse. Cross-referencesiSequence databases
Select the link destinations:EMBLiGenBankiDDBJi mRNA. Translation: . mRNA. Translation: . mRNA. Translation: .
UniGeneiMm.422675. 3D structure databases
ProteinModelPortali
SMRi Positions
MobiDBiProtein-protein interaction databases
STRINGi Chemistry
GuidetoPHARMACOLOGYi Protein family/group databases
GPCRDBiPTM databases
PhosphoSitei Proteomic databases
PRIDEi Protocols and materials databases
Structural Biology KnowledgebaseGenome annotation databases
Ensembli; ; . ; ; .
UCSCi mouse. Organism-specific databases
MGIi P2ry12. Phylogenomic databases
InParanoidi
PhylomeDBi
TreeFami Enzyme and pathway databases
Reactomei P2Y receptors.
ADP signalling through P2Y purinoceptor 12.
G alpha (i) signalling events. Miscellaneous databases
SOURCEiGene expression databases
ExpressionAtlasi baseline and differential.
Genevestigatori Family and domain databases
InterProi GPCR_Rhodpsn.
GPCR_Rhodpsn_7TM.
P2Y12_rcpt.
PANTHERi PTHR24233:SF0. 1 hit.
Pfami 7tm_1. 1 hit.
PRINTSi GPCRRHODOPSN.
P2Y12PRNCPTR.
PROSITEi G_PROTEIN_RECEP_F1_2. 1 hit.
ProtoNetiPublicationsi"The transcriptional landscape of the mammalian genome.", , , , , , , , , , , , , , , , ,
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: . Tissue:
and . "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
[] [] []Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Strain: . Tissue: . "P2Y12 regulates platelet adhesion/activation, thrombus growth, and thrombus stability in injured arteries.", , , , , , , ,
[] [] []Cited for: FUNCTION, DISRUPTION PHENOTYPE. +MiscellaneousiKeywords - Technical termi, Documents
List of 7-transmembrane G-linked receptor entries
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
Index of protein domains and families
External DataSimilar proteinsiLinks to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease.
- PubMed - NCBI
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):473-83. doi: 10.1111/j.12.01420.x. Epub
2012 May 10.P2RY1 and P2RY12 polymorphisms and on-aspirin platelet reactivity in patients with coronary artery disease.1, , , , , , , , , .1Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA.AbstractINTRODUCTION: Association of P2RY1 and P2RY12 polymorphisms with on-aspirin platelet reactivity was investigated.MATERIALS AND METHODS: Platelet reactivity was assessed by the light transmission aggregometry and TxB(2) assay in 423 patients with coronary artery disease (CAD) on aspirin. High residual platelet reactivity (RPR) was defined by ≥20% and ≥70% maximal aggregation stimulated with 0.5 mg/mL arachidonic acid (AA) and 10 μm ADP, respectively. Moderate RPR was considered aggregation ≥20% with AA, ≥70% with ADP, or ≥1 ng/mL stimulated TxB(2) . Fourteen P2RY1 and 35 P2RY12 single nucleotide polymorphisms (SNPs) were genotyped.RESULTS: High RPR was detected in 24% of the patients. Moderate RPR was observed in 31% with AA, 57% with 5 μm ADP, and 82% with 10 μm ADP. Stimulated TxB(2) was ≥1 ng/mL in 23% of patients. P2RY12 SNP rs9859538 was associated with high RPR (OR = 2.16, 95% CI = 1.24-3.75, P-value = 0.004). Four P2RY12 SNPs, rs1491974, rs, rs3732765, and rs, showed association with moderate RPR (OR = 1.79-2.94, P-value = 0.04-0.028), while five, rs7615865, rs1388623, rs1388622, rs7634096, and rs7637803, were associated with low RPR (OR = 0.50-0.55, P-value = 0.008-0.026), following ADP stimulation. TxB(2) level &1 ng/mL was linked to five P2RY1 SNPs, rs1439010, rs1371097, rs701265, rs, and rs2312265 (OR = 0.36-0.54, P-value = 0.003-0.039).CONCLUSIONS: Polymorphisms in P2RY1 and P2RY12 are associated with on-aspirin platelet reactivity in patients with CAD.(C) 2012 Blackwell Publishing Ltd.PMID:
[PubMed - indexed for MEDLINE] PMCID: PMC3419334 Publication TypesMeSH TermsSubstancesGrant SupportFull Text SourcesOther Literature SourcesMedicalMolecular Biology DatabasesMiscellaneous
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