Mithramycin A improves functional recovery by inhibiting BSCB disruption and hemorrhage after spinal cord injury
more authorsAbstractAfter spinal cord injury (SCI), blood spinal cord barrier (BSCB) disruption and progressive hemorrhage lead to secondary injury, subsequent apoptosis and/or necrosis of neuron and glia, causing permanent neurological deficits. Growing evidences indicate that mithramycin A (MA), an anticancer drug, has neuroprotective effects in ischemic brain injury and Huntington's disease. However, the precise mechanism underlying its protective effects is largely unknown. Here, we examined the effect of MA on BSCB breakdown and hemorrhage as well as subsequent inflammation after SCI. After moderate spinal cord contusion injury at T9, MA (150 ug/kg) was immediately injected intraperitoneally and further injected once a day for 5 d. Our data show that MA attenuated BSCB disruption and hemorrhage, and inhibited the infiltration of neutrophils and macrophages after SCI. Consistent with these findings, the expression of inflammatory mediators was significantly alleviated by MA. MA also inhibited the expression and activation of matrix metalloprotease-9 (MMP-9) after injury, which is known to disrupt BSCB and the degradation of tight junction proteins. In addition, the expression of sulfonylurea receptor 1 (SUR1) and transient receptor potential melastatin 4 (TRPM4), which are known to mediate hemorrhage at an early stage after SCI, was significantly blocked by MA treatment. Finally, MA inhibited apoptotic cell death and improved functional recovery after injury. Thus, our results demonstrated that MA improves functional recovery by attenuating BSCB disruption and hemorrhage through the down-regulation of SUR1/TRPM4 and MMP-9 after SCI.Do you want to read the rest of this article?Request full-text
CitationsCitations0ReferencesReferences0Article · Nov 2017 Liwei DongGuodong DongJianye CaoJing ZhangJing ZhangArticle · Nov 2017 +1 more author...Article · Nov 2017 Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.This publication is from a journal that may support self archiving.Last Updated: 22 Oct 17Management of stress urinary incontinence in spinal cord injured female patients with a mid-urethral tape - a single center experience
21.05Agios Pavlos General Hospital, Thessaloniki, Greece+ 326.67Salisbury NHS Foundation TrustShow
more authorsAbstractContext/objective:
Stress urinary incontinence (SUI) affects the quality of life of females with spinal cord injury (SCI), has a negative impact on functional independence and disturbs their psychosocial interaction. Our aim was to assess the efficacy of mid-urethral tapes (MUT) in managing stress urinary incontinence in this population.
Retrospective cohort study.
Participants:
SCI females with upper motor neuron lesion and urodynamically proven stress or mixed urinary incontinence that was treated with a mid-urethral tape and followed up for at least 12 months.
Interventions:
Mid-urethral tapes such TVT, TOT and mini-Arc. Patient reported outcomes based on the daily use of pads and ICIQ modular questionnaire scores.
Outcome measures:
The primary endpoint was defined as the success rate of MUT surgery in managing stress incontinence at 12. The secondary endpoints included the improvement rate at 12 months, the complication rates and the need for additional treatments.
38 females were studied. At 12 months the overall patient reported success rate was 52.6%. 16% reported significant improvement. 68.4% felt the quality of life to improve. Nine patients develop tape related complications (five de novo urgency, one vaginal extrusion, one frequent dysreflexia and one worsening of incontinence).
Conclusion:
Mid-urethral tapes are effective in the management of stress urinary incontinence in female patients with spinal cord injury. There are demonstrable improvements in both continence and quality of life.Do you want to read the rest of this article?Request full-text
CitationsCitations0ReferencesReferences0ProjectAthina Leontidou[...]Evaluate the effect of multiple variables (sex,age,primary
or revision surgery and Preoperative comorbidities) on emergency pediatric neurosurgery. Retrospective observational study. ProjectArticleAugust 2016 · Journal of Clinical UrologyBladder calculi are a common complication of urinary tract augmentation with an incidence of up to 50%.1 Aside from traditional transurethral approaches, management options include lithotripsy,2 or hybrid techniques using a combination of endoscopic and laparoscopic approaches. 3 Although Mitrofanoff cystolitholopaxy has been previously described,4 we describe a further modification of the... ArticleJune 2008 · UroToday International JournalArticleOctober 2016 · Therapeutic Advances in UrologyWe describe a case of accidental intra-ureteric catheter placement in a spinal cord injury patient which was promptly recognized radiologically and describe a simple method of repositioning via fluoroscopy allowing the study to continue to completion. ArticleSeptember 2015 · International braz j urol: official journal of the Brazilian Society of Urology · Impact Factor: 0.88Data provided are for informational purposes only. Although carefully collected, accuracy cannot be guaranteed. Publisher conditions are provided by RoMEO. Differing provisions from the publisher's actual policy or licence agreement may be applicable.This publication is from a journal that may support self archiving.Last Updated: 11 Nov 17Nat Neuronsci:新型病毒载体可以将“货物”在大脑与外周神经中自由运输--《现代生物医学进展》2017年26期
Nat Neuronsci:新型病毒载体可以将“货物”在大脑与外周神经中自由运输
【摘要】：正病毒进化出了高效运送基因进入宿主细胞内部的能力,利用这一现象,研究者们能够将病毒进行重新编程,从而能够让其将特定的基因序列导入细胞中,这些载体因此成为了疾病治疗或神经元标记等方面的重要工具。然而,由于病毒载体已经失去的自我复制的能力,因此难以完成大范围的基因运送。特别地,对于大脑来说,由于血脑屏障的存在,因而基因运输十变得更加困难。
【分类号】：R3416【正文快照】：
病毒进化出了高效运送基因进入宿主细胞内部的能力,利用这一现象,研究者们能够将病毒进行重新编程,从而能够让其将特定的基因序列导入细胞中,这些载体因此成为了疾病治疗或神经元标记等方面的重要工具。然而,由于病毒载体已经失去的自我复制的能力,因此难以完成大范围的基因运
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