broadspectrumspe6666是什么意思思?

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Glycotope Enrolls First Patients in Phase I Trial with TrasGEX, a Glycooptimized HER2 Biobetter Antibody -
Glycotope Enrolls First Patients in Phase I Trial with TrasGEX, a Glycooptimized HER2 Biobetter Antibody
Berlin, Germany, September 19, 2011 / B3C newswire / - Glycotope
GmbH, a leading company in the field of glycomics, announced today
the enrollment of the first patients in a phase I dose finding
trial to evaluate safety and tolerability of TrasGEX(TM).
TrasGEX(TM) is a biobetter of the marketed Trastuzumab /
Herceptin(TM) targeting the HER2-receptor, commonly
overexpressed in a variety of cancers. TrasGEX(TM) has been
glycooptimized to yield a manifold higher anti-tumor activity and
is supposed to be suitable for the treatment of an enlarged patient
spectrum. It was developed using GlycoExpress(TM), the company's
development and production platform based on glycoengineered human
cell lines for biopharmaceuticals with fully human and optimized
glycosylation.
"We are delighted to see our 4th glycooptimized
biopharmaceutical product in clinical trials", says Dr. Steffen
Goletz, CEO, CSO and Founder of Glycotope. "After CetuGEX(TM)
and PankoMab-GEX(TM), TrasGEX is our 3rd anti-cancer antibody
which entered clinical trials in time. GlycoExpress has been proven
to be the broadest glycooptimization technology not only for
antibodies but also for most other glycoproteins. Our
glycooptimized Follicle-Stimulating Hormone FSH-GEX(TM) has
already completed clinical phase Ia with very exciting results.
Currently we are advancing a broad range of pre-clinical products
in various therapeutic areas".
About Glycotope
GLYCOTOPE, founded in 2001 in Berlin, focuses on the optimization
and humanization of therapeutically relevant sugar structures on
biopharmaceuticals known as glycosylation and on the development of
innovative antibodies targeting glycostructures on cell surfaces.
Biologics developed in Glycotope?s GlycoExpress(TM)
technology of glycoengineered human cell lines receive a fully
human and optimized glycosylation, leading to a largely improved
activity, an elongated half-life time and/or reduced immunogenicity
and hence important therapeutic benefits for a significantly
increased number of patients. In addition, the GlycoExpress
platform is superior in productions yields, product quality and
reproducibility compared to other production platforms.
Glycotope?s product portfolio now encompasses a variety of
antibodies and non-antibody biologics, 4 of which are currently in
the clinical stage. This pipeline includes antibodies against novel
targets for cancer therapy (e.g. GT-MAB 2.5-GEX(TM)) and
significantly improved versions of antibodies as well as other
already marketed therapeutic proteins, so called Biobetters.
Together with Glycotope-Biotechnology in Heidelberg, Glycotope
evolved into a leading integrated glycobiology company, covering
all phases in drug development such as lead discovery and
optimization, preclinical and process development, GMP production
and clinical development. With more than 140 employees, the group
has grown to one of the largest Biotech organizations in
Glycotope GmbH
Dr. Franzpeter Bracht
Chief Financial & Business Officer
Robert-Roessle-Str. 10
13125 BERLIN
Tel. +49 (0)30 94 89-2600
Fax: +49 (0)30 94 89-2609
franzpeter.
Posted: September 2011
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Email Addressbroad-spectrum - definition of broad-spectrum by The Free Dictionary /broad-spectrum
broad-spectrum Also found in: , , .
broad-spec·trum (br?d′spĕk′trəm)adj. Widely applicable or effective: a broad-spectrum antibiotic.broad-spectrumn1.
(Pharmacology) (modifier) effective against a wide variety of diseases or microorganisms: a broad-spectrum antibiotic. broad′-spec′trum
(of an antibiotic) effective against a wide range of organisms.
having a wide range of uses.
broad-spectrumadjectiveCovering a wide scope:, , , , , , , , , , , , , , , , , , .
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